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Stephanie Zerwas's avatar

As a former researcher in this space, I have real reservations about whether polygenic risk scores will ever explain enough variability to be genuinely useful for embryo selection. Beyond that, selecting against genetic risk factors often means selecting against traits that may be beneficial in other contexts. Schizophrenia, for example, is genetically correlated with creativity. Anorexia with higher educational attainment. What helps in one environment can cause problems in another.

As these tools start to reach the public, we desperately need better metaphors to explain how genes and environment work together. Our brains default to simple binaries: either it’s genes or it’s environment. But the truth is closer to a four-dimensional mix of genes, both passive and evoked environmental context, and developmental timing.

Explaining that clearly, especially to non-researchers, is hard. But I think the right metaphors can help. Maybe it’s not a genetic blueprint, but a building shaped by materials, construction crews, and weather. Or maybe it’s a jar of risk and resilience, filled gradually over time. This one still sticks with me, and I often use it clinically when trying to explain genetic risk in mental health:

https://mhdss.ac.uk/news/20/09/18/talking-about-risk-and-resilience#:~:text=%5BJar%20Metaphor%3A&text=We%20get%20filled%20up%20with,which%20make%20us%20more%20vulnerable.

I’ve always admired your ability to translate complex psychological ideas clearly. What kinds of metaphors or stories do you think might resonate most with the public? And how do we herd cats (researchers, ethicists, clinicians) so we can tell a more coherant, honest, and nuanced story about genetic influence, especially as technologies like CRISPR and tools like polygenic risk scores become part of the mainstream conversation?

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Will Bennis's avatar

As usual, I appreciate your contrarian and thoughtful perspective. Always makes me think. That said, I don't think you do justice to the counter-argument against the kind of genetic engineering implied above. Here are 4 examples:

(1) the unavoidable conflict between self-interest and the greater good. If everyone custom-chooses their embryos, surely there would sometimes be a cost to the greater good. The example of gender in the essay you referred to is a good one. If 90% of parents prefer one gender in some cultures, that doesn't just impact the individual making the choice, it dramatically changes the sexual makeup of society (just as a low-hanging-fruit example). At the very least, we'd want to think about which aspects of genetic selection should be allowed even if they benefit the family making the decision.

(2) That points the probable impact on genetic diversity. If we're all choosing the ideal human based on our limited understanding of human biological health, we could narrow genetic diversity in ways that are disastrous over the long term. Sure, it wouldn't all be bad (and maybe the net impact would be positive), but at least it is worth careful consideration before relying on intentional choice over biological evolutionary processes that made us such a well-adapted species in the first place.

(3) There are huge implications for class disparity assuming this became a standard human practice. I'm sure you're familiar with plenty of good (or bad) sci-fi pointing to the implications of technological innovations that impact human health and well being (I am fond of Gattica for a eugenics example). Cultural practices like this that have profound implications for what it means to be human that would unavoidably differ across SES surely warrant greater care and hesitation relative to more mundane choices (like whether to take prenatal vitamins).

(4) That points to the extent to which custom-designing humans is a sacred topic in the sense that it is deeply (and rightly) moral, with existential implications for human society and well-being that has evolved through extremely different (and slower) processes than human cost-benefit analysis. On the one hand, that could be used to justify your endorsement of eugenics (CBA is the best we've got!). On the other hand, it seems to similarly justify great care about potential risk and harm as a result of over-reliance on CBA for adaptive, complex systems we still understand so poorly (e.g., biological and cultural evolutionary processes, moral intuitions). Those processes have wisdoms of their own that are often (at least plausibly) more reliable than intentional, deliberative reason (and that are part of what makes people fear the scientist that puts all their faith in human reason above other ways of knowing and deciding).

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